Making Sense Out of a Plethora of Hepatitis C Clinical Trials Results
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چکیده
Like HIV, the replication cycle of hepatitis C virus (HCV) is complex, involving multiple steps and many potential opportunities for pharmacologic inhibition or blockade. Nevertheless, attempts to eradicate HCV have been disappointing and previously have involved using the combination of intravenous interferon (weekly) and oral ribavirin. This combination has been associated with substantial toxicities, does not inhibit directly any step of HCV replication, and has not proved to be particularly effective for the most common genotypes (1a and 1b) in the US—especially in the setting of concomitant HIV co-infection.
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